Artificial cells, blood substitutes, and immobilization biotechnology
-
Artif Cells Blood Substit Immobil Biotechnol · Feb 2012
Fluid resuscitation of hemorrhagic shock with hemoglobin vesicles in Beagle dogs: pilot study.
Resuscitation of hemorrhagic shock requires volume replacement and restoration of oxygen metabolism. Artificial oxygen carriers that can both expand blood volume and deliver oxygen have been developed as resuscitation fluids. We employed hemoglobin vesicles (HbV), a cellular-type artificial oxygen carrier, in a Beagle dog hemorrhagic shock model to prove the efficacy of HbV. ⋯ Serum chemistry data from the HbV group were unremarkable. HbV contributed 32% of the post-resuscitation oxygen delivery. Collectively, HbV is comparable to ASB and HSA as a resuscitation fluid and is an effective oxygen carrier.