Expert opinion on biological therapy
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Expert Opin Biol Ther · Apr 2009
ReviewRilonacept for the treatment of cryopyrin-associated periodic syndromes (CAPS).
Cryopyrin-associated periodic syndromes (CAPS) encompass a group of rare inherited, autoinflammatory disorders that represent a spectrum of one disease with varying degrees of severity. Until recently, there was no effective treatment for CAPS, but identification of the genetic basis of CAPS highlighted the pathogenic role of IL-1beta. ⋯ Rilonacept, the only IL-1 Trap, is the first of many novel IL-1-targeted therapies being developed. In a very short time it has changed the lives of CAPS patients.