Expert opinion on biological therapy
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Expert Opin Biol Ther · Mar 2014
ReviewRecent developments in the treatment of patients with systemic lupus erythematosus: focusing on biologic therapies.
Major trials hoping to obtain optimal disease control in systemic lupus erythematosus (SLE) are ongoing. Given its complex aetiology and pathogenesis, it is not surprising that multiple therapeutic targets have emerged and that none are uniformly successful. ⋯ In addition to targeting B cells, other approaches including biologics, which modulate T-cell function and block interleukin-6 and interferon-α, have been explored. Finally, we review the recent developments in the use of conventional drugs, such as cyclophosphamide and mycophenolate.