Zhongguo fei ai za zhi = Chinese journal of lung cancer
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Zhongguo Fei Ai Za Zhi · Aug 2005
[A randomized control study on the clinical effects of ramosetron in prophylaxis of nausea and vomiting induced by cisplatin chemotherapy in patients with lung cancer].
Cisplatin has remarkable anti-tumor effects against various malignancies. Of its severe adverse reactions, nausea and vomiting are considered to be dose-limiting factors in cisplatin therapy. The anti-emetic properties of 5-HT₃ receptor antiagonists, such as ramosetron, can reduce nausea/vomiting. In order to evaluate the clinical efficacy of ramosetron injection against nausea and vomiting in treatment of cisplatin, a randomized control study was performed to compare the efficacy of anti-nausea and vomiting between ramosetron and ondansetron. ⋯ Ramosetron can effectively prevent the nausea and vomiting induced by cisplatin chemotherapy. The efficacy of ramosetron in controlling nausea and vomiting is better than that of ondansetron.