Zhongguo fei ai za zhi = Chinese journal of lung cancer
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Zhongguo Fei Ai Za Zhi · Jan 2014
Review[Research progress of matrix metalloproteinase 12 in non-small cell lung cancer].
Lung cancer is one of the most common malignant tumors in the world wide. Non-small cell lung cancer (NSCLC) accounts for approximately 80% of lung cancers, its pathogenesis have not been elucidated. Recently, researches have shown that dysregulation and excessive activity of the matrix metalloproteinases (MMPs) has been associated with many pathologies. ⋯ The expression of MMP-12 in non-small cell lung cancer is significantly higher than in adjacent tissues. And studies have shown that the MMP-12 has important prognostic significance in NSCLC. Therefore this article will briefly summarize the research progresses of MMP-12 in NSCLC.