Expert opinion on therapeutic targets
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Expert Opin. Ther. Targets · Jun 2006
ReviewTargets for deep brain stimulation in Parkinson's disease.
The use of stimulation electrodes implanted in the brain to control severely disabling neurological and psychiatric conditions is an exciting and fast emerging area of neuroscience. An excellent example is Parkinson's disease (PD), in which tens of thousands of patients have now been implanted with stimulation electrodes. Patients with PD underwent deep brain stimulation (DBS) at the level of the thalamus, globus pallidus internus, subthalamic nucleus, pedunculopontine nucleus and prelemniscal radiation. ⋯ Clinicians can choose their DBS target based on the situation of their individual PD patients. In the authors' opinion, patient-specific targeting should be preferred over disease-specific targeting. In this review, the authors give an overview of the targets that have been used for DBS in PD and discuss patient-specific targeting.
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Expert Opin. Ther. Targets · Jun 2006
Current targets in irritable bowel syndrome: an interview with Eamonn Quigley. Interview by Emma Quigley.
Eamonn M M Quigley, MD, FACG, is Vice-President of the World Gastroenterology Organisation and Secretary of the American College of Gastroenterology. He is also Professor of Medicine and Human Physiology and Head of the Medical School at the National University of Ireland in Cork. Between 1991 and 1998, he served as Chief of Gastroenterology and Hepatology at the University of Nebraska Medical Center, where he was also Professor in the Department of Internal Medicine. ⋯ His MD thesis was awarded by the National University of Ireland in 1984 and he received his medical education at University College Cork, graduating MB BCh BAO in 1976. Dr Quigley served as Editor-in-Chief of the American Journal of Gastroenterology from 1997 to 2003, and he has published > 400 articles, including original manuscripts, editorials, review articles, book chapters and case reports. He is also interested and involved in education in the area of gastroenterology and has participated in, or directed symposia, workshops and other teaching forums and prepared a variety of related teaching aids.