Expert opinion on therapeutic targets
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Present treatment of medulloblastoma, the most common malignant brain tumor in children, includes surgery, radiotherapy and chemotherapy. In spite of radical treatment, only about 70% of patients survive. Also side effects of the treatment are severe, mostly due to applied radiotherapy. ⋯ The quest for a better treatment modalities includes better risk stratification methods, including molecular profiling of individual tumors and a search for new small molecules capable of inhibiting hyperactive signaling pathways. Several candidates for such agents are being tested presently.