Expert opinion on therapeutic targets
-
Expert Opin. Ther. Targets · Jul 2015
Comparative StudyPolydatin protects hepatocytes against mitochondrial injury in acute severe hemorrhagic shock via SIRT1-SOD2 pathway.
The aim of the study was to determine whether hepatocyte mitochondrial injury instigates severe shock and to explore effective therapy. ⋯ PD effectively preserved hepatocytes from mitochondrial injury via SIRT1-SOD2 pathway and may be a new approach to treatment of irreversible shock.