The spine journal : official journal of the North American Spine Society
-
Mitochondrial dysfunction is recognized during cell senescence and apoptosis, two important components of human disc aging/degeneration. We hypothesize that mitochondrial dysfunction is present in the degenerating and senescent annulus cells. The objective of the present study was to analyze gene expression profiles related to mitochondrial function in vivo. ⋯ Novel data showed that significant gene expression patterns are present in the human annulus related to mitochondrial dysfunction; changes were identified in important genes involving apoptosis, eNOS and Msr expressions, and solute carrier genes. Because current research efforts are focusing on bioactive compounds for mitochondria, we suggest that future biologic cell-based therapies for annulus degeneration should also consider mitochondrial-focused therapies.
-
Laminectomy for lumbar stenosis-associated radiculopathy is associated with improvement in pain, disability, and quality of life. However, given rising health-care costs, attention has been turned to question the cost-effectiveness of lumbar decompressive procedures. The cost-effectiveness of multilevel hemilaminectomy for radiculopathy remains unclear. ⋯ Multilevel hemilaminectomy improved pain, disability, and quality of life in patients with lumbar stenosis-associated radiculopathy. Total cost per QALY gained for multilevel hemilaminectomy was $33,700 when evaluated 2 years after surgery with Medicare fees, suggesting that multilevel hemilaminectomy is a cost-effective treatment of lumbar radiculopathy.
-
The integrity of the posterior ligamentous complex (PLC) has been proposed to be an integral aspect in the treatment algorithm for spinal trauma. Magnetic resonance imaging (MRI) has been reported as the ideal tool to determine the integrity of the PLC. The ability to assess disruption of the PLC by reviewers of differing levels of training has not been described. In addition, the MRI sequence most suggestive of injury for each component of the PLC has not been clearly determined. ⋯ The interpretation of traumatic MRI is very sensitive and accurate regardless of years of training of the observer. The attending-level spine surgeon was statistically more specific in the evaluation of injury MRIs. The fluid-weighted STIR sagittal sequences are most useful in determining injury to the SSL, ISL, LF, and cervical facets capsules. Lumbar facet capsules are best evaluated with axial T2 MRI. The evaluation of the PLC on MRI can be accurately and efficiently interpreted by physicians at multiple levels of training, thus providing a key imaging modality in determining stability and need for stabilization.
-
Randomized Controlled Trial
No difference in long-term trunk muscle strength, cross-sectional area, and density in patients with chronic low back pain 7 to 11 years after lumbar fusion versus cognitive intervention and exercises.
Reduced muscle strength and density observed at 1 year after lumbar fusion may deteriorate more in the long term. ⋯ Although this study did not assess the morphology of muscles likely damaged by surgery, trunk muscle strength and cross-sectional area above the surgical levels are not different between those who had lumbar fusion or cognitive intervention and exercises at 7- to 11-year follow-up.