The spine journal : official journal of the North American Spine Society
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Ambulation limitation is the hallmark of impairment in lumbar spinal stenosis (LSS). Capacity and performance have been defined as two distinct aspects of disability. Previous literature suggests that a person's walking capacity may not be reflected in their daily walking performance. ⋯ Walking capacity and walking performance in LSS appear to be different constructs. Survey instruments appear to reflect capacity rather than performance. This dissociation between walking capacity and walking performance has implications for the clinical management and outcomes assessment of people with LSS.
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Surgical indications for lumbar burst fracture remain controversial. Potential indications for surgery include 50% canal compromise, 50% loss of vertebral height, 30° of kyphosis, and posterior element fracture or disruption of the posterior ligamentous complex. Different surgical approaches are available depending on fracture characteristics. It is possible that a minimally invasive approach could allow for a safe and effective treatment with fewer comorbidities than the traditional open technique. ⋯ The traditional approach to an anterior lumbar corpectomy and posterior pedicle screw fixation involves significant postoperative pain and frequent ileus. This minimally invasive approach allowed for early mobilization, resumption of diet, and discharge from the hospital on postoperative day two.
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Patients with thoracic tuberculosis have been not always successfully treated by radical debridement and bone grafting with or without supplementary posterior instrumentation and fusion, although most surgeons use posterior instrumentation to support anterior strut grafts. ⋯ The authors think that the one-stage anterior autogenous rib grafts and instrumentation are safe and effective methods in the surgical management of thoracic tuberculosis.
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Mitochondrial dysfunction is recognized during cell senescence and apoptosis, two important components of human disc aging/degeneration. We hypothesize that mitochondrial dysfunction is present in the degenerating and senescent annulus cells. The objective of the present study was to analyze gene expression profiles related to mitochondrial function in vivo. ⋯ Novel data showed that significant gene expression patterns are present in the human annulus related to mitochondrial dysfunction; changes were identified in important genes involving apoptosis, eNOS and Msr expressions, and solute carrier genes. Because current research efforts are focusing on bioactive compounds for mitochondria, we suggest that future biologic cell-based therapies for annulus degeneration should also consider mitochondrial-focused therapies.
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Pedicle screws are now standard for spinal arthrodesis as they provide three-column spinal stabilization. Decreased vertebral body bone density because of aging reduces the stability of the bone-screw interface, potentially increasing screw pullout or pseudarthrosis. Modifications to standard pedicle screw designs to improve screw stabilization may help to compensate for the detrimental effects of decreased vertebral bone density. ⋯ Expandable titanium pedicle screws demonstrated improved screw pullout stability compared with standard titanium screws in osteopenic or osteoporotic bone. Further studies are warranted examining other loading methods to evaluate the stability provided by an expandable pedicle screw.