Articles: analgesics.
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Randomized Controlled Trial Multicenter Study Clinical Trial
Tiger Balm as a treatment of tension headache. A clinical trial in general practice.
To assess the efficacy of a topical medication, Tiger Balm, in the treatment of acute tension headache. ⋯ There was a statistically significant difference (p < 0.05) in headache relief between Tiger Balm and placebo. The difference between Tiger Balm and medication was not significant.
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Int J Clin Pharmacol Res · Jan 1996
Randomized Controlled Trial Multicenter Study Clinical TrialOral tramadol and buprenorphine in tumour pain. An Italian multicentre trial.
In this multicentre trial tramadol and buprenorphine were compared for the treatment of neoplastic pain no longer responsive to non-steroidal antiinflammatory drugs. A total of 131 adults (86 M, 45F) were treated with tramadol (one 100-mg slow-release tablet every 8-12 h), or buprenorphine (one sublingual 0.2-mg tablet every 6-8 h). The trial was to continue for up to six months. ⋯ There were six drop-outs in the first group (9%) and seven in the second (11%). Serious symptoms arose more frequently in the buprenorphine group (19% cf. 10%). No signs of dependence or tolerance were noted.
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Fortschritte der Medizin · Nov 1995
Randomized Controlled Trial Multicenter Study Clinical Trial[Effectiveness of flupirtine in chronic tension headache. Results of a double-blind study versus placebo].
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Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial
The effectiveness of combined oral lysine acetylsalicylate and metoclopramide compared with oral sumatriptan for migraine.
Aspirin is commonly used to treat migraine attacks, although sumatriptan, a much more expensive treatment, is also effective. We compared a combination of lysine acetylsalicylate (equivalent to 900 mg aspirin) and 10 mg metoclopramide (LAS+MTC) with oral sumatriptan (100 mg) and placebo in 421 patients with migraine. LAS+MTC was as effective as sumatriptan with a decrease of headache from severe or moderate to mild or none of 57% and 53%, respectively, for the first migraine attack treated. ⋯ LAS+MTC was significantly more effective in the treatment of nausea than sumatriptan (p < 0.0001) and was better tolerated (adverse events in 18% and 28%, respectively, p < 0.05). LAS+MTC is as effective as sumatriptan in the treatment of migraine attacks. It is also much cheaper.
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Fortschritte der Medizin · Jul 1994
Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial[Treatment of tumor pain with flupirtine. Results of a double-blind study versus tramadol].
In a multicentric double-blind trial, flupirtine was compared with tramadol in the treatment of cancer pain. ⋯ Initially comparable in the two groups, pain was more markedly reduced after four weeks of treatment with flupirtine than after tramadol, the need for additional analgesic drugs also being less in the flupirtine group. The final general assessment by the attending doctors of the results achieved was "good" to "very good" in 63% of the patients on flupirtine, and in 46% of those on tramadol. Undesired effects were observed in 6% of the flupirtine patients and in 19% of those taking tramadol.