Articles: analgesia.
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Randomized Controlled Trial Clinical Trial
Effects of perioperative analgesic technique on rate of recovery after colon surgery.
Choice of perioperative analgesia may affect the rate of recovery of gastrointestinal function and thus duration and cost of hospitalization after colonic surgery. ⋯ Epidural analgesia with bupivacaine and morphine provided the best balance of analgesia and side effects while accelerating postoperative recovery of gastrointestinal function and time to fulfillment of discharge criteria after colon surgery in relatively healthy patients within the context of a multimodal recovery program.
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Anesthesia and analgesia · Oct 1995
Randomized Controlled Trial Clinical TrialDetermination of the minimum local analgesic concentrations of epidural bupivacaine and lidocaine in labor.
The aim of this study was to devise a clinical model to determine the effective concentrations in 50% of patients (EC50) for bupivacaine and lidocaine in the first stage of labor and define EC50 as the minimum local analgesic concentration (MLAC). This should allow the determination of relative analgesic potency and, subsequently, the local anesthetic sparing efficacy of other epidural analgesics. Parturients not exceeding 5 cm cervical dilation who requested epidural analgesia were enrolled. ⋯ MLAC was determined using the formula of Dixon and Massey. Results show MLAC bupivacaine 0.065% (95% confidence interval [CI] 0.045-0.085), MLAC lidocaine 0.37% (95% CI 0.32-0.42), equivalent to 2 and 14 mmol solutions, respectively. Thus bupivacaine was 5.7 times more potent than lidocaine in weighted and 7 times more potent in molar ratios at analgesic EC50, in the volume of local anesthetic studied.
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1. Recent findings have further helped to elucidate the mechanisms involved in the transmission and modulation of pain. ⋯ In response to these findings, new agents and techniques have been applied in the clinical setting and new approaches have been developed to use existing agents more effectively. This review presents some of the findings from recent studies and the implications they have for the management of pain.
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The Journal of urology · Oct 1995
Comparative StudyAn outcome study of patient-controlled morphine analgesia, with or without ketorolac, following radical retropubic prostatectomy.
We compared the effects of postoperative pain control strategies on recovery after radical retropubic prostatectomy. ⋯ Pain control with ketorolac affords excellent analgesia while allowing for earlier recovery of bowel function, shorter hospitalization and lower overall costs in patients undergoing radical retropubic prostatectomy.