Articles: postoperative-pain.
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Paediatric anaesthesia · Jul 2004
Randomized Controlled Trial Clinical TrialRofecoxib administration to paediatric patients undergoing adenotonsillectomy.
Rofecoxib is a selective COX-2 inhibitor that does not interfere with platelet function and is associated with fewer bleeding complications than other nonsteroidal anti-inflammatory agents (NSAIDs). Our aims were to evaluate the safety and the efficacy of rofecoxib administration to paediatric patients undergoing adenotonsillectomy (T&A). ⋯ Rofecoxib administration to paediatric patients undergoing T&A did not result in increased bleeding. Rofecoxib, however, was not found to decrease morphine use or improve pain scores prior to hospital discharge in T&A patients who received intraoperative morphine and acetaminophen.
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Acta Anaesthesiol Scand · Jul 2004
Randomized Controlled Trial Comparative Study Clinical TrialEffects of post-operative pain treatment using non-steroidal anti-inflammatory analgesics, opioids or epidural blockade on systemic and local immune responses in children.
Many studies have been carried out on the effects of anaesthetic drugs and methods on the immune response, but pain and its relief also affect the immune response. We measured systemic immune responses in the blood circulation and local responses in the surgical wound when non-steroidal anti-inflammatory analgesics (NSAIDs), opioids or epidural blockade was used in the peri-operative treatment of pain. ⋯ Post-operative pain treatments using diclofenac (NSAID), oxycodone (opioid) and epidural blockade have basically similar effects on systemic and local immune responses with only slight, probably clinically unimportant differences in children undergoing surgery under general anaesthesia.
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Randomized Controlled Trial Clinical Trial
Randomized controlled trial of preservation or elective division of ilioinguinal nerve on open inguinal hernia repair with polypropylene mesh.
Our study aimed to evaluate the effect of preservation or elective division of the ilioinguinal nerve on pain and postoperative symptoms after open inguinal hernia repair with mesh. ⋯ Pain after open hernia repair with polypropylene mesh is not affected by elective division of the ilioinguinal nerve; sensory disturbances in the area of distribution of the transected nerve are significantly increased.
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Clinical therapeutics · Jul 2004
Randomized Controlled Trial Clinical TrialOnset of analgesia and analgesic efficacy of tramadol/acetaminophen and codeine/acetaminophen/ibuprofen in acute postoperative pain: a single-center, single-dose, randomized, active-controlled, parallel-group study in a dental surgery pain model.
The combination of tramadol and acetaminophen has demonstrated good efficacy in various clinical pain models. However, there is a need for comparisons of the onset of analgesia and other measures of analgesic efficacy with this combination and other strong combination analgesics for the management of acute pain. ⋯ In this small and selected group of subjects, the onset of analgesia and analgesic efficacy of Tr/Ac was comparable to that of Co/Ac/Ib. Tr/Ac provided rapid and effective analgesia for acute postoperative dental pain in this population.
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Management of acute postoperative pain remains suboptimal; nearly 80 % of the patients report moderate to extreme pain following surgery. Nonselective nonsteroidal antiinflammatory drugs (NSAIDs) have a role in postoperative pain management, but conventional NSAIDs can cause gastrointestinal ulceration, renal injury, and disruption of platelet function and hemostasis. ⋯ These drugs have demonstrated analgesic efficacy and opioid sparing effect after variety of surgical procedures. This article will review the role and outcome of COX-2 inhibitors for postoperative pain management.