Articles: postoperative-pain.
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Surg Gynecol Obstet · Sep 1984
Comparative StudyComparison of analgesic activity of buprenorphine hydrochloride and morphine in patients with moderate to severe pain postoperatively.
Since buprenorphine has been reported to be effectively analgesic yet free of addiction potential, two single-dose, double-blind, parallel studies were conducted to compare its analgesic activity and safety with those of morphine. The patients in each study consisted of patients experiencing moderate to severe postoperative pain. ⋯ The degree of sedation, vital signs and side effects were evaluated. Buprenorphine generally appeared comparable to morphine in the onset and duration of action and in side effect liability.
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Int J Clin Pharmacol Ther Toxicol · Sep 1984
Comparative Study Clinical TrialDezocine for postoperative wound pain.
We assessed the analgesic effectiveness of a single intramuscular injection of dezocine, 10 mg or 15 mg; morphine, 10 mg; or a placebo in 160 patients with moderate to severe postoperative pain. Dezocine, 10 mg, was as effective as and had approximately the same duration of action as morphine, 10 mg. ⋯ A small percentage of patients suffered nausea and became sedated; the drugs and placebo, however, did not differ statistically with respect to the side effects. Blood pressure, heart rate, and respiratory rate generally were slightly decreased by both drugs.
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Randomized Controlled Trial Comparative Study Clinical Trial
[Analgesia and adverse effects of nalbuphine (Nubain) in comparison with morphine following hysterectomy].
In a randomized double-blind-study nalbuphine 20 mg i.m. was compared with morphine 10 mg i.m. in 49 patients over the first 48 postoperative hours after hysterectomy. Nalbuphine proved to be a good analgetic, not statistically different from morphine but having statistically significantly fewer side effects.