Articles: low-back-pain.
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Jornal de pediatria · Nov 2020
Low back pain in adolescents and association with sociodemographic factors, electronic devices, physical activity and mental health.
To determine the prevalence of low back pain and to analyze the association with the individual, sociodemographic variables, electronic devices, habitual practice of physical activity, and mental health problems. ⋯ There is a high prevalence of low back pain in high school students and striking association with female sex, electronic devices, and mental health problems.
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Discogenic pain is common cause of low back ache and may result in significant morbidity. Platelet-rich plasma (PRP) is an upcoming regenerative therapy that has treatment potential for this condition. The objective of this study was to correlate platelet concentration in intradiscal PRP injection with improvement in low back pain and functional status at three and six months. ⋯ This study supports the use of intradiscal PRP for treatment of discogenic pain with preferably higher platelet counts to elicit a favorable response.
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Biomed. Pharmacother. · Nov 2020
ReviewThe role of IL-1β and TNF-α in intervertebral disc degeneration.
Low back pain (LBP), a prevalent and costly disease around the world, is predominantly caused by intervertebral disc (IVD) degeneration (IDD). LBP also presents a substantial burden to public health and the economy. IDD is mainly caused by aging, trauma, genetic susceptibility, and other factors. ⋯ Therefore, anti-IL-1β and anti-TNF-α therapies may have the potential to alleviate disc degeneration and LBP. In this paper, we reviewed the expression pattern and signal transduction pathways of IL-1β and TNF-α, and we primarily focused on their similar and different roles in IDD. Because IL-1β and TNF-α inhibition have the potential to alleviate IDD, an in-depth understanding of the role of IL-1β and TNF-α in IDD will benefit the development of new treatment methods for disc degeneration with IL-1β and TNF-α at the core.
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Clin Neurol Neurosurg · Nov 2020
Proposal for a new scoring system for spinal degeneration: Mo-Fi-Disc.
We aimed to develop a new scoring system for spinal degeneration including Modic changes, fatty infiltration (fi) in the paraspinal muscles, and intervertebral disc degeneration (IVDD), briefly Mo-fi-disc, using current radiological classification systems. We also aimed to understand whether Mo-fi-disc could predict patients with more intense low back pain (LBP). ⋯ Patients with more intense LBP had higher 'Mo-fi-disc' scores. This scoring system suggests an easy and objective classification to evaluate the spinal degeneration.