Articles: low-back-pain.
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Modulation of pain perception by oxytocin (OXT) has attracted increased scientific and clinical interest. Neural mechanisms underlying these effects are poorly understood. In this study, we aimed to investigate the effects of intranasally applied OXT on intrinsic neural activity in patients with chronic low back pain (cLBP). ⋯ Our data suggest significant oxytocin-related modulation of intrinsic regional activity and neural network strength in patients with chronic low back pain and healthy controls. In patients, distinct regions of the pain matrix may be responsive to modulation by oxytocin. Therapeutic effects of oxytocin for improved pain treatment need to be further investigated.
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Complement Ther Clin Pract · May 2020
Meta AnalysisEfficacy and safety of moxibustion for chronic low back pain: A systematic review and meta-analysis of randomized controlled trials.
To systematically review and meta-analyze the efficacy of moxibustion in treating patients with chronic low back pain (CLBP). ⋯ It is difficult to draw firm conclusions that moxibustion is an effective intervention for treating CLBP due to the small sample size of eligible trails and the high risk of bias among the available articles. Rigorously designed large-scale RCTs are required to further confirm the results in this review.
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Randomized Controlled Trial
The effect of spinal manipulation on brain neurometabolites in chronic nonspecific low back pain patients: a randomized clinical trial.
In patients with chronic nonspecific low back pain (NCLBP), brain function changes due to the neuroplastic changes in different regions. ⋯ In the patient with low back pain, spinal manipulation affects the central nervous system and changes the brain metabolites. Consequently, pain and functional disability are reduced.