Articles: chronic-pain.
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Chronic pain
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Eur. J. Clin. Invest. · Feb 2025
Clinical measures in chronic neuropathic pain are related to the Kennedy and endocannabinoid pathways.
Chronic neuropathic pain (CNP) is a debilitating condition, often refractory to currently available drugs. Understanding biochemical alterations in peripheral tissues such as blood will be useful for understanding underlying pathophysiological processes relating to CNP. ⋯ Endocannabinoid levels, expression of genes related to endocannabinoid metabolism, age, sex, depression and anxiety state together were strong predictors of CNP. The observed molecular changes indicate that lipid metabolism is altered in CNP and thus may represent a viable target for novel analgesics or biomarker development.