Articles: neuralgia.
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Molecular neurobiology · Oct 2020
Optogenetic Activation of Dopamine Receptor D1 and D2 Neurons in Anterior Cingulate Cortex Differentially Modulates Trigeminal Neuropathic Pain.
Anterior cingulate cortex (ACC) is a critical brain center for chronic pain processing. Dopamine signaling in the brain has been demonstrated to contribute to descending pain modulation. However, the role of ACC dopamine receptors in chronic neuropathic pain remains unclear. ⋯ We observed that dopamine receptors D1 and D2 in the ACC are primarily expressed in excitatory neurons and that the D2 receptor is differentially regulated in the early and late phases of trigeminal neuropathic pain. Optogenetic activation of D1-expressing neurons in the ACC markedly exacerbates CCI-ION-induced trigeminal neuropathic pain in both early and late phases, but optogenetic activation of D2-expressing neurons in the ACC robustly ameliorates such pain in its late phase. Our results suggest that dopamine receptors D1 and D2 in the ACC play different roles in the modulation of trigeminal neuropathic pain.
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Dorsal root entry zone (DREZ) lesioning is an effective method to treat refractory neuropathic pain in patients with radicular avulsion. In this procedure, we penetrate the spinal cord with a radiofrequency electrode using the posterior lateral sulcus as a guide. ⋯ Here we present a case of a patient with radicular avulsion lesion of rootlets of the cervical spinal cord successfully treated with DREZ lesioning using intraoperative ultrasound as a guide to perform the spinal cord lesions. The use of intraoperative ultrasound during DREZ lesioning in patients with radicular avulsion improves the neurosurgeon ability to precisely localize the posterior lateral sulcus and also to better define the correct angulation of the trajectory.