Articles: neuralgia.
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Randomized Controlled Trial Clinical Trial
Differential effects of neuropathic analgesics on wind-up-like pain and somatosensory function in healthy volunteers.
To investigate the effects of gabapentin, carbamazepine, and amitriptyline on temporal summation, simple nociceptive pain, and innocuous touch sensation in healthy volunteers. ⋯ We have shown that gabapentin, carbamazepine, and amitriptyline, three pharmacologically different drugs, have distinct and quantifiable effects on somatosensory pathways in healthy volunteers. These findings provide a link between pharmacology of the study drugs and clinical effectiveness. The effects of gabapentin and carbamazepine on temporal summation pain show that these drugs can block centrally amplified wind-up pain in the absence of a neuropathic disorder.
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Randomized Controlled Trial Clinical Trial
Divalproex sodium in the management of post-herpetic neuralgia: a randomized double-blind placebo-controlled study.
Post-herpetic neuralgia is difficult to treat. Divalproex sodium (valproic acid and sodium valproate in molar ratio 1:1) has been used successfully in the management of various painful neuropathies. ⋯ Divalproex sodium provides significant pain relief in patients of post-herpetic neuralgia, with very little incidence of adverse reactions. These data provide a basis for longer trials in a larger group of patients.
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Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial
Pregabalin relieves symptoms of painful diabetic neuropathy: a randomized controlled trial.
Pregabalin, an alpha2-delta ligand with analgesic, anxiolytic, and anticonvulsant activity, has been evaluated for treatment of neuropathic pain. The authors assessed the efficacy and tolerability of pregabalin (75, 300, 600 mg/day) vs placebo in patients with diabetic peripheral neuropathy (DPN). ⋯ In patients with diabetic peripheral neuropathy, pregabalin demonstrated early and sustained improvement in pain and a beneficial effect on sleep, which were confirmed by positive patient global impression. Pregabalin was well tolerated at all doses.
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Acta Neurol. Scand. · Oct 2004
Randomized Controlled Trial Multicenter Study Clinical TrialTopiramate in painful diabetic polyneuropathy: findings from three double-blind placebo-controlled trials.
To evaluate the efficacy and tolerability of topiramate in patients with painful diabetic polyneuropathy. ⋯ These studies did not find topiramate to be significantly more effective than placebo in reducing pain scores in patients with painful diabetic polyneuropathy. Several design features may have precluded the studies from having sufficient sensitivity to differentiate effective and ineffective treatments. The study design and results are instructive for other investigators designing future clinical studies in neuropathic pain.
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Journal of neurology · Oct 2004
Randomized Controlled Trial Comparative Study Clinical TrialA placebo-controlled trial of gabapentin for painful HIV-associated sensory neuropathies.
Painful HIV-associated sensory neuropathies (HIV-SN) are a common complication of HIV infection. The pathogenesis is unknown and the treatment very limited. Gabapentin (GBP) is effective in painful diabetic neuropathy and postherpetic neuralgia and its effectiveness on painful HIV-SN has been reported anecdotally. ⋯ GBP was more effective than placebo in reducing pain and sleep interference in patients with HIV-SN.