Articles: function.
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Cardiovascular Case Report Posters ISESSION TYPE: Case Report PosterPRESENTED ON: Sunday, March 23, 2014 at 01:15 PM - 02:15 PMINTRODUCTION: For regional anesthesia, lidocaine bupivacaine combination is popular due to the advantage of quick onset action of lidocaine and longer duration of action of bupivacaine. Although a safe procedure, toxicity from local anesthetics can result from local absorption and/or inadvertent direct IV injection. Direct cardiac toxic effects of local anesthetics involve arrhythmias and/or direct myocardial injury/ suppression. A recent study showed that bupivacaine induce mitochondrial swelling in myocarium with resultant negative inotropic effects. Bupivacaine in high doses or unintentional intravascular injection may lead to high plasma levels and related depression of the myocardium, heart block, hypotension, bradycardia, ventricular arrhythmias, and cardiac arrest. There is very limited echocardiographic and ventriculographic evidence of bupivacaine induced cardiac dysfunction. ⋯ This case describes inverted takotsubo cardiomyopathy as a mechanism for bupivacaine induced cardiac suppression and demonstrates the need for increased awareness of the rare but serious cardiotoxic effects of bupivacaine when used for nerve blocks.Reference #1: Coyle DE et el Anesth Analg. 1994 Aug; 79(2):335-339DISCLOSURE: The following authors have nothing to disclose: Martinus Dyrud, Rakesh Gupta, Rumi KhanNo Product/Research Disclosure Information.
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Critical Care Posters IISESSION TYPE: Poster PresentationsPRESENTED ON: Saturday, March 22, 2014 at 01:15 PM - 02:15 PMPURPOSE: We have previously demonstrated in a clinically relevant murine model of sepsis, that a phenotype of left ventricular (LV) dilation was associated with improved cardiovascular performance (stroke volume (SV) and cardiac output (CO)) and increased survival. Using the same model of sepsis, we sought to determine whether survival in mice that did not manifest dilation was associated with a particular phenotype. ⋯ The following authors have nothing to disclose: Fabien Picard, François Depret, Sergio Zanotti-Cavazzoni, Steven HollenbergNo Product/Research Disclosure Information.
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Critical Care Posters IISESSION TYPE: Poster PresentationsPRESENTED ON: Saturday, March 22, 2014 at 01:15 PM - 02:15 PMPURPOSE: Echocardiography is an important tool for evaluating cardiac and hemodynamic functions in small animals but requires sedation and immobility, which influences cardiac performance. Minimizing the hemodynamic effects of anesthesia is extremely important for improving applicability of animal models to the clinical setting, especially in models of shock. We aimed to evaluate the effects of isoflurane dose on myocardial function in a murine model, and to attempt to compare very low doses of isoflurane to a state in which the mice were off anesthesia. ⋯ The following authors have nothing to disclose: Fabien Picard, François Depret, Sergio Zanotti-Cavazzoni, Steven HollenbergNo Product/Research Disclosure Information.