Articles: function.
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Lung Ventilation/Perfusion Scan With SPECT-CT on Two Patients With Congenital Thoracic Malformation.
Congenital Disorder Case Report PostersSESSION TYPE: Case Report PosterPRESENTED ON: Sunday, March 23, 2014 at 01:15 PM - 02:15 PMINTRODUCTION: Poland syndrome was first describe by Alfred Poland in 1941, as the presence of syndactyly and the partial or complete absence of ipsilateral chest muscle, although is more common to find absence on its sternocostal portion, with or without absence of the minor pectoral. Pectus excavatum is a congenital deformity of the anterior wall of the thorax, in which the costal cartilages grow abnormally. In previous studies the quantitative evaluation of the lung volume has been reported with scintigraphy with the SPECT-CT technique with 99m Tc macroaggregates formulation, having as a goal to determine the favorable changes of the surgical reconstruction by Thoracoscopy assisted NUSS procedure on patients with pectus excavatum. After the bibliographic review, there were no reports found for the lung function evaluation by the SPECT-CT technique on any thoracic malformation. ⋯ Is expected to provide, beside the morphological evaluation by conventional imaging tests, a functional technique with nuclear medicine by the lung ventilation/ perfusion scan with SPECT-CT technique to determine the lung function and changes of the secondary lung parenchymal to congenital alterations of the thoracic cage, keep monitoring and reevaluate the lung function after surgical treatment.Reference #1: Pearl, Pediatric Radiology Poland Syndrome 1971;101:619-62 2. Pinedo Presentación de un caso de corrección cosmética de pectus excavatum Rev INER 2005;18:117-122 3. Mansour Ann Thorac Surg 2003;76:391-395 4. Protopapas, Journal of Cardiothoracic Surgery 2008,3:40 5. Onur, Ann Saudi Med 2006;26(5):370-374 6. Schanberger, General Thoracic Surgery, 2005 6th ed, Chapter 41DISCLOSURE: The following authors have nothing to disclose: Sigelinda Sandoval Borrego, Francina BolanosI agree.
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Critical Care Case Report PostersSESSION TYPE: Case Report PosterPRESENTED ON: Sunday, March 23, 2014 at 01:15 PM - 02:15 PMINTRODUCTION: Diffuse alveolar hemorrhage (DAH) is associated with negative pressure pulmonary edema secondary to acute upper airway obstruction. There have been no associations with the upper airway obstruction of obstructive sleep apnea. Negative intrathoracic pressure leads to an increase in pulmonary vascular volume and pulmonary capillary transmural pressure, creating a risk of disruption of the alveolar-capillary membrane. We present a case of DAH in a patient on anticoagulation with positive anti-cardiolipin antibody and low level anti-dsDNA triggered by severe obstructive sleep apnea. ⋯ The following authors have nothing to disclose: Sadaf Mir, Silviana Marineci, Mary O'SullivanNo Product/Research Disclosure Information.
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Critical Care Posters IISESSION TYPE: Poster PresentationsPRESENTED ON: Saturday, March 22, 2014 at 01:15 PM - 02:15 PMPURPOSE: Echocardiography is an important tool for evaluating cardiac and hemodynamic functions in small animals but requires sedation and immobility, which influences cardiac performance. Minimizing the hemodynamic effects of anesthesia is extremely important for improving applicability of animal models to the clinical setting, especially in models of shock. We aimed to evaluate the effects of isoflurane dose on myocardial function in a murine model, and to attempt to compare very low doses of isoflurane to a state in which the mice were off anesthesia. ⋯ The following authors have nothing to disclose: Fabien Picard, François Depret, Sergio Zanotti-Cavazzoni, Steven HollenbergNo Product/Research Disclosure Information.
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Mechanical ventilation is crucial for patients with respiratory failure. The mechanical takeover of diaphragm function leads to diaphragm dysfunction and atrophy (ventilator-induced diaphragmatic dysfunction), with an increase in oxidative stress as a major contributor. In most patients, a sedative regimen has to be initiated to allow tube tolerance and ventilator synchrony. Clinical data imply a correlation between cumulative propofol dosage and diaphragm dysfunction, whereas laboratory investigations have revealed that propofol has some antioxidant properties. The authors hypothesized that propofol reduces markers of oxidative stress, atrophy, and contractile dysfunction in the diaphragm. ⋯ Propofol does not protect against ventilator-induced diaphragmatic dysfunction or oxidative injury. Notably, spontaneous breathing under propofol sedation resulted in the same amount of diaphragm atrophy and dysfunction although diaphragm activation per se protects against ventilator-induced diaphragmatic dysfunction. This makes a drug effect of propofol likely.