Articles: pain.
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Clinical Trial Controlled Clinical Trial
Antagonism of nitrous oxide analgesia by naloxone in man.
The possible reversal of nitrous oxide analgesia by naloxone was investigated. Two studies were conducted in 21 healthy male subjects, who responded to ischemic pain produced by tourniquet applied to the upper arm for 15 min, while breathing air or nitrous oxide, 33 per cent. Using a double-blind procedure, the subjects received intravenous injections of naloxone and saline solution on different days. ⋯ In 13 subjects, naloxone, 4 mg, also decreased significantly the effect of nitrous oxide analgesia in comparison with saline solution. Naloxone showed its reversal effect mainly on sensory response rating obtained during the painful stages of ischemia, between 11 and 15 min. The results suggest that analgesia induced by nitrous oxide may be partly related to the opiate receptor--endorphin system in man.
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In the treatment of cancer, particularly when pain is a serious symptom, psychological support of a patient is important and can, in fact, facilitate ongoing oncologic treatment. Hypnosis represents a psychological technique of great potency for reducing pain, increasing patients' life-enhancing attitudes, and helping patients deal with death and separation. Ultimately, the value of hypnosis lies in enabling an individual to potentiate inner capacities for creating psychological quiescence and physical comfort. For a suffering cancer patient, relief that comes from within can provide a much-needed experience of personal efficacy and strength.