Articles: pain.
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Clin. Pharmacol. Ther. · Apr 1980
Randomized Controlled Trial Comparative Study Clinical TrialNefopam and propoxyphene in episiotomy pain.
To evaluate relative efficacy, safety, and time course of analgesia, nefopam (45 and 90 mg), a new centrally acting nonnarcotic analgesic, was compared with propoxyphene (65 mg) and placebo in a single oral dose, parallel, stratified, randomized, double-blind trial with 100 hospitalized postpartum women with medium or severe episiotomy pain. Using subjective reports as indices of response, patients rated pain intensity and side effects at periodic interviews for 6 hr. ⋯ Side effects included mild dizziness and hypothermia after nefopam and mild elevation of diastolic arterial pressure after nefopam and propoxyphene. Our results suggest that 45- and 90-mg doses of nefopam induced more analgesia than 65 mg propoxyphene in the relief of episiotomy pain.
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Comparative Study Clinical Trial
Clinical evaluation of zomepirac and APC with codeine in the treatment of postpartum episiotomy pain.
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Comparative Study Clinical Trial
Clinical comparison of zomepirac with APC/codeine combination in the treatment of pain following oral surgery.
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Comparative Study Clinical Trial
Double-blind comparisons of zomepirac and oxycodone with APC in cancer pain.
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Journal of neurosurgery · Apr 1980
Retrospective analysis of 22 patients with chronic pain treated by peripheral nerve stimulation.
Twenty-two patients with chronic pain, chiefly from posttraumatic neuropathy, were treated by implanted peripheral nerve stimulators located proximal to the pain. Thirteen of these (62%) have experienced pain control for an average of 25 months. ⋯ There are theoretical and practical advantages to electrical stimulation and proximal portions of the peripheral nervous system. The surgical technique for implantation is described and the necessity for reoperation in some patients is explained.