Articles: pain.
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Clinical Trial Controlled Clinical Trial
Relative analgesic potency of oral zomepirac and intramuscular morphine in cancer patients with postoperative pain.
A twin crossover assay of oral zomepirac and intramuscular morphine was completed in 159 cancer patients with postoperative pain. Zomepirac was a surprisingly effective oral analgesic in these patients, 100 mg orally being roughly equivalent to 16 mg intramuscular morphine. ⋯ Side effect occurrence was roughly in the same range for both drugs, with drowsiness, nausea, dry mouth, and feelings of weakness being observed after both drugs while sweating was observed more frequently after zomepirac. The assay further provided a demonstration of the effectiveness of the twin crossover design as a clinical assay method, providing increased sensitivity of crossover data in a patient population available for only a limited number of study treatments.
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Comparative Study Clinical Trial
A controlled repeat-dose comparison of zomepirac and clometacin in pain after plastic surgery.
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Clin. Pharmacol. Ther. · Apr 1980
Randomized Controlled Trial Comparative Study Clinical TrialNefopam and propoxyphene in episiotomy pain.
To evaluate relative efficacy, safety, and time course of analgesia, nefopam (45 and 90 mg), a new centrally acting nonnarcotic analgesic, was compared with propoxyphene (65 mg) and placebo in a single oral dose, parallel, stratified, randomized, double-blind trial with 100 hospitalized postpartum women with medium or severe episiotomy pain. Using subjective reports as indices of response, patients rated pain intensity and side effects at periodic interviews for 6 hr. ⋯ Side effects included mild dizziness and hypothermia after nefopam and mild elevation of diastolic arterial pressure after nefopam and propoxyphene. Our results suggest that 45- and 90-mg doses of nefopam induced more analgesia than 65 mg propoxyphene in the relief of episiotomy pain.
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Comparative Study Clinical Trial
Clinical evaluation of zomepirac and APC with codeine in the treatment of postpartum episiotomy pain.