Articles: ninos.
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Presenting to primary care with fatigue is associated with a wide range of conditions, including cancer, although their relative likelihood is unknown. ⋯ This study ranked the likelihood of possible diagnoses in patients who presented with fatigue, to inform diagnostic guidelines and doctors' decisions. Age-specific findings support recommendations to prioritise cancer investigation in older men (aged ≥70 years) with fatigue, but not in women at any age, based solely on the presence of fatigue.
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Meta Analysis
Causal effects of the RANK-RANKL-OPG system and scoliosis: A bidirectional 2-sample Mendelian randomization study.
Epidemiological studies and a recent Mendelian randomization (MR) study have identified an association between low bone mass and an increased risk of scoliosis. Previous research suggests that bone loss in patients with scoliosis may be related to the RANK-RANKL-OPG system. This study is to investigate whether a causal relationship exists between the RANK-RANKL-OPG system and the development of scoliosis. ⋯ However, no significant relationship was found between scoliosis with the RANK-RANKL-OPG system. This research establishes a basis for further exploration of the pathophysiological mechanisms and potential targeted treatments for scoliosis. Future studies are necessary to understand how OPG influences the development of scoliosis.
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Randomized Controlled Trial
Advantages of using touch-controlled, minimally invasive implantation technique on soft tissue in the aesthetic zone of maxillary anterior teeth.
Endosseous implant is an ideal treatment option for the treatment of denture defects and omissions. However, how to maintain the perfect gum contour of patients has been an important research topic for stomatologists and has attracted much attention. The objective of this study was to explore the advantages of minimally invasive touch-controlled implantation in maintaining soft tissue morphology in the aesthetic area of maxillary anterior teeth. ⋯ The H values (the distance from the labial edge of the implant healing cap to the lowest gingival margin), 6 weeks after surgery, of 2 groups were 2.69 and 3.05, respectively, P = .023. There was a significant difference in patient satisfaction between 2 groups 24 hours after surgery (P < .001). Touch-controlled minimally invasive implantation has shorter operative time and lesser bleeding, postoperative pain, and gingival recession than traditional flap implantation, which is conducive to the preservation of gingival shape.
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Practice Guideline
Clinical Practice Guideline: Condylar Hyperplasia of the Mandible—Diagnosis and Treatment.
Condylar hyperplasia of the mandible is characterized by abnormal size and configuration of the condylar process. In Germany, the administrative prevalence of diagnosed and/or treated condylar hyperplasia is 2.4-9.6 cases per 100 000 persons. Misdiagnosis is common and can lead to severe esthetic and functional complications, including facial deformity that can progress into the patient's twenties, as well as dysfunctional speech and mastication. ⋯ Condylar hyperplasia is a common, but not widely known problem. Its early diagnosis and treatment can prevent severe jaw asymmetry and further complications such as craniomandibular dysfunction and arthrosis of the temporomandibular joints.
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Paediatric otorrhoea (PO) is a symptom-based diagnosis encompassing acute and chronic ear infections that cause otorrhoea in children and young people (CYP). ⋯ To the authors' knowledge, this is the first longitudinal population-based study investigating PO that demonstrates the burden on primary care. Antimicrobial prescribing predominantly follows National Institute for Health and Care Excellence guidelines using oral amoxicillin. Aminoglycosides are the most frequently prescribed topical antibiotic despite the concern of ototoxicity.