Articles: respiratory-distress-syndrome.
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Wien. Klin. Wochenschr. · Sep 1987
[Can muscle relaxation prevent the development of pneumothorax in artificially ventilated newborn infants?].
A retrospective study was conducted on 37 ventilated newborn infants to find out whether muscle paralysis by pancuronium had prevented pneumothorax (pt) in those severely ill newborn infants. In the group of 21 newborns who developed pt, 17 (81%) had been paralyzed with pancuronium. ⋯ Since the newborns in both groups were equally severely ill (mean compliance of the respiratory system 0.48 +/- 0.17 ml/cm H20 in the group with pt, 0.38 +/- 0.12 in the group without pt), we assume that pancuronium was unable to prevent pt in ventilated premature and full-term newborn infants. We therefore caution against the use of pancuronium as a paralytic drug known to have deleterious side effects.
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Acta Paediatr Scand · Sep 1987
Comparative Study Clinical Trial Controlled Clinical TrialComparison of different rates of artificial ventilation in preterm neonates with respiratory distress syndrome.
The effectiveness of three different ventilator rates of artificial ventilation (30, 60 and 120/min) was studied in 32 preterm infants, all of whom were suffering from the Respiratory Distress Syndrome (16 were paralysed). Ventilator pressures, I:E ratio and MAP were kept constant at each rate. ⋯ Two different ventilators were used in the study and a significant change in PaCO2 (reduction) occurred only in non-paralysed infants ventilated at a rate of 120/min by Sechrist ventilators (p less than 0.05). This difference may be a direct reflection of differences in ventilator performance at fast rates.
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The activity of the right external abdominal oblique muscle, in relation to respiration, in newborn babies from 25 to 34 weeks' gestation was studied, using surface electrodes. Babies without respiratory difficulties showed no activity associated with respiration in these muscles. ⋯ This activity continued when the babies were endotracheally intubated; if the babies were ventilated it sometimes disturbed the tidal ventilation delivered by the machines. When the baby expired during a ventilator inflation, so that gas came up the endotracheal tube against the inflating pressure, the abdominal oblique muscles contracted in 98% of the breaths.
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The case presented here is typical of the localized fibrous mesotheliomas reviewed in the literature. It had a disastrous impact on an otherwise unremarkable pregnancy. There is no discussion in the literature of humeral factors related to localized fibrous mesotheliomas, but the fever, chills, and rheumatoid complaints in some patients may suggest such factors. ⋯ Anticoagulation led to hemorrhage from the thin-walled vascular areas of the tumor. This acute bleeding produced the hypovolemic shock on the third postpartum day, with a cascade of events leading to adult respiratory distress syndrome and the patient's ultimate death. This case underscores the importance of broad differential diagnosis as a continuing challenge in the practice of medicine.