Articles: brain-injuries.
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Zh Vopr Neirokhir Im N N Burdenko · Jan 1989
[Prevention and treatment of postoperative complications of acute traumatic intracranial hematoma].
Timely application of adequate diagnostic and therapeutic measures, reoperations among others, allows mortality to be reduced to 33% in postoperative epidural hematomas, to 50% in recurrent intracranial hematomas, and by 19% in edema and swelling of the brain with its compression. Methods of neurosurgical prevention of complications, the use of an inflow-outflow dialysis system and removal of crushed brain areas attendant to the hematomas in the first place, are the leading factor in improving the outcomes of the treatment of acute traumatic intracranial hematomas.
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General categories of experimental brain injury models are reviewed regarding their clinical significance, and two new models are presented that use different methodology to produce injury. This report describes and characterizes the pathophysiologic changes produced by a novel fluid percussion (FP) method and a controlled cortical impact (CI) technique, both developed at the General Motors Research Laboratories (GMRL). The new models are compared to prior experimental brain injury techniques in relation to ongoing physical and analytical modeling used in automotive safety research by GMRL. ⋯ These controlled variables enable the amount of deformation and the change in deformation over time to be accurately determined. In addition, the CI model produces graded, reproducible cortical contusion, prolonged functional coma, and extensive axonal injury, unlike the FP technique. The quantifiable nature of the single mechanical input used to produce the injury allows correlations to be made between the amount of deformation and the resultant pathology and functional changes.(ABSTRACT TRUNCATED AT 400 WORDS)