Article Notes
- Despite this history we remain unprepared for a pandemic.
- From an ICU perspective, conservative models predict >170% ICU resource utilisation due to a pandemic. They note that most health systems would struggle with even this optimistic surge.
- SARS experience in Canada, despite only 251 cases, critically stretched hospital and ICU resources.
- Pandemic surveillance.
- Prepare health-system scalability to manage surge: equipment, physical space, human resources, and system (eg. stepped triage plans).
- Prepare for mass vaccine production.
- Better coordinate and integrate communications.
- Streamlined research and ethics proposals for rapid initiation.
- Virtue ethics – behaving in the way we think is right; embodying courage.
- Utilitarianism – behaving so as to maximise the best outcomes for the greater number of people.
- Deontology – obeying the rules; following a duty to moral law.
- Principlism – balances beneficence, nonmaleficence, autonomy and justice.
- It is clinical outcomes that primarily matter, and;
- Simulation is uniquely positioned to address improvements in the many domains of teamwork.
What is this?
Kain & Fowler's prescient review from October 2019 sets out how intensive care units should prepare and respond to the next pandemic, both practically at a hospital level and at a wider health-system. Although the focus was on an influenza pandemic, the advice is readily applicable to the SARS-COV-2 pandemic.
Background
They note that not only have we seen regular influenza outbreaks in addition to other viral pandemics, that due to increased urbanisation, population density, global travel and living proximity to animals, there is rapidly increasing global risk of a viral pandemic.
"When considering preparation for the next pandemic, it is not a matter of if it will occur, but rather a matter of when." – Kain & Fowler
They provide an overview of historical influenza pandemics over the last century, most recently with the 2009 H1N1 swine-flu pandemic, killing 300,000 people.
What preparation do they recommend?
Kain and Fowler suggest global focus on:
They highlight the importance of intensivists being involved in strategic planning, so as to coordinate ICU responses for "...triage, clinical care, and infection control." – noting that during SARS 20% of infections were in healthcare workers, and hospitals themselves became important sources of transmission.
Final word...
The IHR Committee's review following the 2009 H1N1 pandemic is now only too obvious:
“...the world is ill-prepared to respond to a severe influenza pandemic or to any similarly global, sustained, and threatening public-health emergency.” – International Health Regulations Committee (2011)
Daniel Jolley
An exploration of the ethics, challenges and practical reality of treating family members. Hutchison & McConnell deploy models of virtue, utilitarianism, deontology and principlism in an accessible and applied way.
They cautiously challenge the blanket prohibitions of many professional bodies against treating family members.
Well worth reading.
“Only by constantly questioning whether they are the correct person to deliver care can they hope to do right by both their relative and themselves.”
Daniel Jolley
Why is this important?
Although we have moved beyond routinely using high tidal volumes in favour of ’protective ventilation strategies’ the specifics of what is protective and what improves outcomes is controversial. Previous trials have struggled to demonstrate post-operative respiratory benefits from protective strategies.
What did they do?
In this small randomised controlled trial, Généreux et al. investigated whether intraoperative PEEP (7 cmH2O) and recruitment manoeuvres (RM) q30min would reduce atelectasis post-extubation. Using ultrasound to measure intraoperative and post-operative atelectasis gives their study greater flexibility than other studies using CT scanning, generally considered the gold standard for atelectasis measurement.
And they found...
Among 34-85 yo women undergoing open gynae-oncology surgery >2h duration, there was no post-extubation difference in atelectasis whether receiving PEEP/RM or zero PEEP.
Not so fast
There was however less intraoperative atelectasis among the protective ventilation group, supporting the common use of PEEP and RM to improve oxygenation during surgery. Additionally, they specifically excluded morbidly obese women (BMI > 40 kg/m2), an increasingly common demographic at risk of ventilation challenges.
Nonetheless this study adds to the evidence that current protective ventilation strategies do not actually reduce post-operative respiratory complications.
Be smart
One interesting observation was the large amount of inter-patient variability, the researchers noting:
“...this heterogeneity highlights the need to dynamically monitor lung aeration changes and personalise our delivery of mechanical ventilation in the perioperative setting.”
As with many perioperative interventions, the benefits may in fact lie in the personalisation of our care for each individual patient.
Daniel Jolley
Why is this important?
Most simulation research focuses on skills and knowledge (the easiest factors to measure), even though:
Brazil et al. applied a relational coordination (RC) framework to understand teamwork-aspects of simulation research, particularly as these impact wider institutional and healthcare system performance.
“The RC framework — shared knowledge, shared goals and mutual respect in the context of communication that is timely, accurate, frequent and problem-solving based — can provide a common language for simulation educators to design and debrief simulation exercises that aim to have a translational impact” (Brazil et al. 2019)
What did they do?
The researchers undertook a narrative survey of staff involved in early major trauma care at a university teaching hospital. Over half of the respondents had participated in the institution’s existing in situ trauma simulation program.
Survey responses were analysed using the RC framework, and found to be consistent with each RC domain. Most notably trauma simulation acted as an enabler of mutual respect and improved communication, along with enhancing the understanding of team roles and prioritising problem-solving focused communication.
The take-home
The impact of simulation needs to be understood in the context of the greater goal – healthcare system improvement – and that this occurs with pre-existing organisational cultures and relationships. Simulation outcomes goals are not exclusive to small teams or individual performance.
The various domains within the relational coordination framework provide an easy to use guide for understanding, communicating and deploying simulation benefits, drawing a path from the ‘here’ to the ‘there’ of improved outcomes.
“Simulation should be considered as a tool to build and strengthen relationships between practitioners across traditional boundaries.”
Daniel Jolley
This editorial accompanied the 2004 study from Ekman, the first published evidence showing a reduction in awareness when BIS monitoring is used to monitor depth of anaesthesia.
Ekman’s findings were shortly after confirmed by Myles et al. in their landmark 2004 B-Aware Trial.
This editorial and the two related studies are well worth reading to give historical context to the emergence of reliable depth-of-anaesthesia monitors.
Daniel Jolley
Why is this important?
In-hospital cardiac arrest (IHCA) training is an important component of both foundational and continuing medical education. Nonetheless patient survival after IHCA continues to vary across institutions, making it a priority for improvement.
What did they do?
Josey and team set out to identify whether greater hospital use of in-situ AHCI drills (‘in-situ mock codes’ - ISMC) was associated with improved IHCA survival. They measured both hospital-level simulation participation and IHCA discharge survival rates across 26 hospitals in their US multi-state non-profit health system.
And they found?
Hospitals with more active in-hospital cardiac arrest simulation training also had better IHCA survival (43% vs 32%, OR 0.62), even after adjusting for case-mix and acuity.
It is reasonable to conclude that better in-hospital code training leads to better basic & advanced life support and thus better IHCA survival – suggested, for example, by their observation of shorter time to defibrillation during arrest drills among high participation hospitals.
In fact they extraopated that each additional 1.1 drill/100 beds/year equated with one extra life saved. Interestingly the benefit of ISMC held up for large and medium-sized hospitals, but not small hospitals (=< 25 beds).
Be smart
Whether these results represent a direct casual effect of simulation training to improve survival, or an indirect effect of hospital safety culture on both simulation participation and patient survival, it is nonetheless an important result.
Plus a great example of studying a meaningful outcome (survival to discharge) instead of surrogate markers often employed in resuscitation and simulation research.
Daniel Jolley