• Int J Med Sci · Jan 2020

    Review

    The Role of Cyclooxygenase-2 in Colorectal Cancer.

    • Juan Sheng, Hong Sun, Fu-Bing Yu, Bo Li, Yuan Zhang, and Ying-Ting Zhu.
    • Department of Gastroenterology, the Second People's Hospital of Yunnan Province, Kunming, Yunnan 650021, China.
    • Int J Med Sci. 2020 Jan 1; 17 (8): 1095-1101.

    AbstractColorectal cancer is the third common cancer in this world, accounting for more than 1 million cases each year. However, detailed etiology and mechanism of colorectal cancer have not been fully understood. For example, cyclooxygenase-2 (COX-2) and its product prostaglandin E2 (PGE2) have been closely linked to its occurrence, progression and prognosis. However, the mechanisms on how COX-2 and PGE2-mediate the pathogenesis of colorectal cancer are obscure. In this review, we have summarized recent advances in studies of pathogenesis and control in colorectal cancer to assist further advances in the research for the cure of the cancer. In addition, the knowledge gained may also guide the audiences for reduction of the risk and control of this deadly disease.© The author(s).

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