• Corey S Davis, Amy Judd Lieberman, Hector Hernandez-Delgado, and Carli Suba.
• Network for Public Health Law, Los Angeles, CA, USA; Brody School of Medicine, East Carolina University, Greenville, NC, USA. Electronic address: davis@healthlaw.org.
• Drug Alcohol Depend. 2019 Jan 1; 194: 166-172.

BackgroundOpioid overdose is a continuing public health crisis. In response to an increasing recognition of the negative outcomes sometimes associated with the use of opioid analgesics, states have taken a number of steps attempting to reduce inappropriate prescribing of these medications. These include the imposition of strict legal limitations on the amount or duration that opioid analgesics may be prescribed or dispensed to patients with acute pain.MethodsWe conducted a systematic, multi-source legal review of state laws that impose mandatory limits on the ability of medical professionals to prescribe or dispense opioids for the treatment of acute pain. We also systematically searched for and examined publicly available documents on state legislative and regulatory bodies' websites. All relevant laws were downloaded and systematically coded.ResultsBy the end of 2017, twenty-six states had passed laws that impose mandatory limits on the prescribing or dispensing of opioids for acute pain. The oldest of these laws became effective as early as 1989, but most are much newer: approximately 65% (17/26) were passed in 2017. There is wide variation in the characteristics of these laws.ConclusionJust over half of all states have enacted laws that restrict the prescribing or dispensing of opioids for acute pain. To date, there is no data on whether and to what extent these laws mediate opioid-related morbidity and mortality, as well as whether they are associated with negative unintended outcomes. Research into these questions is urgently needed.Copyright © 2018 Elsevier B.V. All rights reserved.

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