• Darko Orešković, Marina Raguž, Nina Predrijevac, Ante Rotim, Dominik Romić, Ana Majić, Patricija Sesar, Marcela Živković, Tonko Marinović, and Darko Chudy.
• Department of Neurosurgery, Clinical Hospital Dubrava, Zagreb, Croatia. Electronic address: darkoreskov@gmail.com.
• World Neurosurg. 2020 Sep 1; 141: e553-e558.

BackgroundGlioblastomas are among the most common primary brain tumors with an abysmal prognosis. The significance of glucose metabolism in glioblastoma cell metabolism and proliferation is well-known. However, a significant correlation between the systemic metabolic status of the patient and the cellular proliferation of the glioblastoma has not yet been established.MethodsOur aim was to observe and analyze for a possible correlation between glioblastoma cellular proliferation and patients' glycated hemoglobin (HbA1c) levels as a marker of chronic systemic glycemia. We analyzed the data from 25 patients and compared their Ki-67 values with their preoperative HbA1c values.ResultsWe observed a statistically significant correlation (P < 0.03) between chronic glycemia (measured using HbA1c) and the cellular proliferation of glioblastoma (measured by cellular Ki-67 expression).ConclusionsThese results imply a possible positive correlation between glioblastoma cell proliferation and chronic systemic glycemia, a correlation that, to the best of our knowledge, has not yet been reported. Further research in this area could not only lead to a better understanding of glioblastoma but also have significant clinical applications in treating this devastating disease.Copyright © 2020 Elsevier Inc. All rights reserved.

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