• Mayo Clinic proceedings · Aug 2020

    Randomized Controlled Trial Multicenter Study Comparative Study

    Effect of Acupuncture in Patients With Irritable Bowel Syndrome: A Randomized Controlled Trial.

    • Lixia Pei, Hao Geng, Jing Guo, Guohui Yang, Lin Wang, Rongrong Shen, Shuyu Xia, Min Ding, Hua Feng, Jin Lu, Jing Li, Lian Liu, Yanye Shu, Xiangdong Fang, Xiaoliang Wu, Xiaoxiao Wang, Shengjie Weng, Lu Ju, Xiao Chen, Hong Shen, and Jianhua Sun.
    • Jiangsu Province Hospital of Chinese Medicine, Nanjing, China.
    • Mayo Clin. Proc. 2020 Aug 1; 95 (8): 1671-1683.

    ObjectiveTo evaluate the effect and safety of acupuncture for the treatment of irritable bowel syndrome (IBS) through comparisons with those of polyethylene glycol (PEG) 4000 and pinaverium bromide.Patients And MethodsThis multicenter randomized controlled trial was conducted at 7 hospitals in China and enrolled participants who met the Rome III diagnostic criteria for IBS between May 3, 2015, and June 29, 2018. Participants were first stratified into constipation-predominant or diarrhea-predominant IBS group. Participants in each group were randomly assigned in a 2:1 ratio to receive acupuncture (18 sessions) or PEG 4000 (20 g/d, for IBS-C)/pinaverium bromide (150 mg/d, for IBS-D) over a 6-week period, followed by a 12-week follow-up. The primary outcome was change in total IBS-Symptom Severity Score from baseline to week 6.ResultsOf 531 patients with IBS who were randomized, 519 (344 in the acupuncture group and 175 in the PEG 4000/ pinaverium bromide group) were included in the full analysis set. From baseline to 6 weeks, the total IBS-Symptom Severity Score decreased by 123.51 (95% CI, 116.61 to 130.42) in the acupuncture group and 94.73 (95% CI, 85.03 to 104.43) in the PEG 4000/pinaverium bromide group. The between-group difference was 28.78 (95% CI, 16.84 to 40.72; P<.001). No participant experienced severe adverse effects.ConclusionAcupuncture may be more effective than PEG 4000 or pinaverium bromide for the treatment of IBS, with effects lasting up to 12 weeks.Trial RegistrationChinese Clinical Trials Register, ChiCTR-IOR-15006259.Copyright © 2020 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.

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