• J Coll Physicians Surg Pak · Apr 2020

    Association of Gleason score with PSA Values and Serum Testosterone Levels Measured Prior To Prostate Biopsy.

    • Muhammed Cihan Temel, Caner Ediz, Serkan Akan, Eymen Ozer, and Omer Yilmaz.
    • Department of Urology, Nevsehir State Hospital, Nevsehir, Turkey.
    • J Coll Physicians Surg Pak. 2020 Apr 1; 30 (4): 399-402.

    ObjectiveTo analyse the association of prostate cancer (PCa) Gleason score evaluated upon prostate biopsy with clinical PSA values, total and free testosterone (TT and FT, respectively) levels measured prior to biopsy.Study DesignA descriptive study.Place And Duration Of StudyDepartment of Urology, Sultan Abdulhamid Han Education and Research Hospital, from July to December 2019.MethodologyA total of 85 patients were included and classified into non-PCa (group 1) and PCa (group 2) groups according the results of prostate biopsy pathology. Age, digital rectal examination (DRE) findings; prostate volume (PV); free/total prostate specific antigen (PSA) ratio (f/tPSA); PSA density (PSA-D) and total PSA (tPSA), free PSA (fPSA), TT and FT levels of the two groups were evaluated. Associations of the ISUP grade of patients in group 2 with age, DRE findings for PCa; PV; PSA-D; f/tPSA and tPSA, fPSA, TT and FT levels were analysed.ResultsMean patient age was 63.00 (57.50-70.00) years. Mean age, significant DRE findings for PCa, tPSA levels and PSA-D were significantly higher in group 2 (p <0.05), whereas PV was significantly higher in group 1 (p <0.05). The ISUP grade of patients in group 2 was significantly and positively correlated with age and tPSA levels (p <0.05). ISUP grade was significantly and positively correlated with significant DRE findings for PCa (p <0.05). However, ISUP grade was negatively correlated with PV and f/tPSA (p <0.05). No significant difference was observed between the two groups in terms of TT and FT levels (p >0.05).ConclusionTT and FT levels evaluated before prostate biopsy did not provide any additional benefit in predicting Gleason score grade before biopsy. Key Words: Prostate biopsy, prostate cancer, ISUP grade, Gleason score, total testosterone, free testosterone.

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