• Yan Jun Si, Qi Wei Guo, Xu Chen, Mei Yang, Jia Lin, and Ding Zhi Fang.
• Department of Biochemistry and Molecular Biology, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, P. R. China.
• Eur. J. Clin. Invest. 2020 Nov 1; 50 (11): e13322.

BackgroundRelationships between tumour necrosis factor receptor 2 (TNF-RII), suicidal ideation and levels of serum lipids have not been reported yet. The present study was to explore lipids profiles in Chinese adolescents with different genotypes of TNF-RII rs1061622 and with or without suicidal ideation.MethodsDietary intakes were surveyed by questionnaires. TNF-RII rs1061622 genotypes were examined by polymerase chain reaction restriction-fragment length polymorphism and verified by DNA sequencing. Lipids levels were examined by routine methods.ResultsHigher TC/HDL-C levels were observed in the subjects with suicidal ideation than those without suicidal ideation in the male students, but no significant differences were found in the female counterparts. When both TNF-RII rs1061622 and suicidal ideation were considered, although there was no significant difference of suicidal ideation prevalence between the TT homozygotes and the G allele carriers, the G allele carriers had elevated levels of TG and TG/HDL-C compared with the TT homozygotes only in the female subjects with suicidal ideation. The subjects with suicidal ideation had higher TG/HDL-C levels than those without suicidal ideation only in the female G allele carriers. Both suicidal ideation and TNF-RII rs1061622, together with BMI, gender and fat intakes, were found the predictors of TG/HDL-C levels. Different relationship patterns of lipids levels were discovered between male and female subjects with different genotypes and with or without suicidal ideation.ConclusionsDifferent changes of lipids profiles between the subjects with or without suicidal ideation may result from not only the genders, but also their interactions with TNF-RII rs1061622.© 2020 Stichting European Society for Clinical Investigation Journal Foundation. Published by John Wiley & Sons Ltd.

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