European journal of clinical investigation
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Eur. J. Clin. Invest. · Nov 2020
Observational StudyTicagrelor and prasugrel are independent predictors of improved long-term survival in ACS patients.
To investigate the long-term clinical benefit of dual antiplatelet therapy with potent P2Y12 inhibitors compared to clopidogrel in patients with acute coronary syndrome (ACS). ⋯ In the setting of ACS, treatment with ticagrelor or prasugrel reduced long-term mortality and 1-year MACE as compared to clopidogrel.
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Eur. J. Clin. Invest. · Nov 2020
ReviewCIMT as a risk factor for Stroke Subtype: A Systematic Review.
An increase in the common carotid artery intima-media thickness (CCA-IMT) is generally considered an early marker of atherosclerosis and is a well-established predictor of cardiovascular disease (CVD). An association between changes in CCA-IMT and risk of stroke has been reported but has conflicting findings. ⋯ Carotid intima thickness measurements are found to be associated with the risk of stroke along with its subtypes and may be used as a diagnostic marker for predicting the risk of stroke events.
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Eur. J. Clin. Invest. · Nov 2020
Review Meta Analysis Comparative StudyEfficacy of various treatment modalities for nCOV-2019: a systematic review and meta-analysis.
Several therapeutic agents have been investigated for treatment of novel coronavirus 2019 (nCOV-2019). We conducted a systematic review and meta-analysis to assess the efficacy of various treatment modalities in nCOV-2019 patients. ⋯ Our meta-analysis suggests that except in vitro studies, no treatment has shown overall favourable outcomes in nCOV-2019 patients. Lopinavir-ritonavir, remdesivir and tocilizumab may have some benefits, while hydroxychloroquine administration may cause harm in nCOV-2019 patients. Results from upcoming large clinical trials may further clarify role of these drugs.
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Eur. J. Clin. Invest. · Nov 2020
A simple score to predict early death after kidney transplantation.
Few studies have focused on risk stratification for premature death after transplantation. However, stratification of individual risk is an essential step in personalized care. ⋯ The ORLY score discriminates patients with high risk of early death.