• Medicine · Apr 2020

    Serum uric acid to creatinine ratio and metabolic syndrome in postmenopausal Chinese women.

    • Jing Tao, Xin Shen, Jie Li, Erdenbat Cha, Pei-Pei Gu, Jun Liu, Wei Zhu, Lin-Long He, Guo-Qing Li, and Zhao Wang.
    • Department of Cardiology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, PR China.
    • Medicine (Baltimore). 2020 Apr 1; 99 (17): e19959e19959.

    AbstractThis study aimed to investigate the association between Serum Uric Acid (UA) to Creatinine (Cr) Ratio (UA/Cr) and metabolic syndrome (MetS) in postmenopausal women.A total of 455 patients with MetS and 457 age- and gender- matched controls were included in the present retrospective study. Serum levels of total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), fasting plasma glucose (FPG), Cr, and UA were measured. We employed logistic regression analysis to investigate the association between serum UA/Cr and MetS in postmenopausal women.Serum UA/Cr levels were significantly higher in patients with MetS than that in control subjects (P < .05). In the correlation analysis, serum UA/Cr showed a significantly positive correlation with age, hypertension, systolic pressure (SBP), diastolic pressure (DBP), Waist, body mass index (BMI), TG, UA and negative correlation with type 2 diabetes mellitus (T2DM) and Cr (P all < .001). Moreover, multivariate analysis revealed that serum UA/Cr was still an independent risk factor for MetS (OR = 2.928, 95% CI = 2.385-3.596, P < .001) after adjustments for other confounders.Serum UA/Cr are strongly associated with the risk of MetS in postmenopausal Chinese women.

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