• Anna Szymańska, Anna E Płatek, Karolina Semczuk-Kaczmarek, Filip M Szymański, and Mirosław Dłużniewski.
• Department of Heart Diseases, Medical Centre of Postgraduate Education, Warsaw, Poland. anna.szymanska@cmkp.edu.pl
• Pol. Arch. Med. Wewn. 2020 Aug 27; 130 (7-8): 635-639.

Introduction2MACE is a risk assessment score designed to stratify cardiovascular risk in patients with atrial fibrillation (AF). Early detection of increased cardiovascular risk is of vital importance in this population, as it helps reduce mortality and morbidity rates.ObjectivesThis study aimed to assess the utility of the 2MACE score in predicting long‑term mortality in patients with AF.Patients And MethodsThis was a post hoc analysis of a prospective observational cohort study including consecutive patients with nonvalvular AF, who were followed for a median duration of 81 months.ResultsThe final analysis included 1351 patients (men, 53.1%; median [interquartile range] age, 71 [62-80] years). During the follow‑up, 142 patients (10.5%) died. Deceased patients were more often classified as high risk according to the 2MACE score than survivors (80.3% vs 53.2%; P <0.0001). The receiver operator characteristic curve analysis demonstrated that the 2MACE score had a good predictive value for long‑ term all cause mortality (area under the curve, 0.73; 95% CI, 0.69-0.78). The mortality rate was significantly increased in patients with a 2MACE score of 3 or higher (hazard ratio, 3.40; 95% CI, 2.33-5.49).ConclusionsThe 2MACE score is a good predictor of long‑ term all cause mortality in patients with AF. A progressive increase in the mortality rate was observed with an increasing 2MACE score.

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