• Asburce Olgac, Asli Inci, Ilyas Okur, Fatih Ezgu, Gursel Biberoglu, and Leyla Tumer.
• Department of Pediatrics, Division of Pediatric Metabolism and Nutrition, Gazi University School of Medicine, Turkey.
• J Coll Physicians Surg Pak. 2019 Dec 1; 29 (12): 1207-1211.

ObjectiveTo evaluate vitamin D levels and bone mineral density in patients with dietary limitations due to inborn errors of metabolism (IEM) and its correlation with diets.Study DesignRetrospective study.Place And Duration Of StudyDepartment of Pediatrics, Division of Pediatric Metabolism and Nutrition, Gazi University Hospital, Turkey, from March to Semtember 2016.MethodologyThe study is a retrospective review of 115 patients. Information about vitamin D status, bone mineral density (BMD) measurement and anthropometric parametres were collected. Patients were divided into two major groups, receiving protein-restricted diets (n=83) and lactose-restricted diets (n=32). Data of 110 healthy children were used as the control group.ResultsMean vitamin D level of patients with special diets 28.1 ±14.9 ng/ml while mean level of healthy controls was 26.6 ±12.27 ng/ml. Levels of 26.8% (n=26/97) patients were found to be deficient and 34% (n=33/97) were found to be insufficient. No statistically significant differences were found between vitamin D levels and BMD of patients and healthy controls. BMD was not influenced by vitamin D levels.ConclusionLow BMD may be encountered in IEM, independent of vitamin D levels and revision of diet for adequacy of essential nutrients; and follow-up for dietary compliance is inevitable.

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