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J Coll Physicians Surg Pak · Dec 2019
Effect of Docetaxel Combined with Cisplatin Preoperative Neoadjuvant Chemotherapy for Stage III NSCLC.
- Guocheng Ma, Wei Chen, and Minquan Ma.
- Department of Respiratory, Lanzhou General Hospital, Lanzhou Military Area Command,730000,China.
- J Coll Physicians Surg Pak. 2019 Dec 1; 29 (12): 1230-1231.
AbstractThe aim of this study was to investigate the effect of docetaxel plus cisplatin preoperative neoadjuvant chemotherapy in stage III non-small cell lung cancer (NSCLC). It was an analytical study carried out from May 2013 to May 2017. Eightytwo patients with stage III NSCLC were divided into Group A and B according to a random number table (n=41). Group A received neoadjuvant chemotherapy with docetaxel plus cisplatin before surgery. Group B underwent surgical treatment after preoperative examination. Compared with group B,operation time of group A was shorter (p<0.001); intraoperative blood loss of group A was lower (p<0.001); surgical resection rate and 1-year survival rate in group A were higher (p=0.013, 0.023). This suggested that preoperative neoadjuvant chemotherapy with docetaxel plus cisplatin may improve surgical resection rate, shorten operation time, reduce intraoperative blood loss, and prolong survival of patients.
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