• Bulent Atik, Tugba Kula Atik, Hulya Duran, Ozgur Baykan, Tuba Ersal, Emine Avci, Emre Ispir, and Bayhan Bektore.
• Faculty of Medicine, Department of Anesthesiology and Reanimation, Balıkesir University, Turkey.
• J Coll Physicians Surg Pak. 2020 May 1; 30 (5): 485-489.

ObjectiveTo investigate the erythrocyte autoantibody positivity detected in the serological cross-matching (XM), and its  possible effects on salient hemogram parameters.Study DesignA descriptive study.Place And Duration Of StudyBalıkesir Atatürk City Hospital's Blood Transfusion Centre, Faculty of Medicine, Department of Anesthesiology and Reanimation, Balıkesir University, Turkey, from 2017 to 2018.MethodologyErythrocyte autoantibody positivity, which was detected in the traditional serological cross-matching for a pre-transfusion laboratory test were analysed retrospectively. Later, hemogram changes in the previous (no erythrocyte autoantibodies) and following (erythrocyte autoantibodies present) transfusions were investigated using statistical methods.ResultsErythrocyte autoantibody positivity rate was 10.16% (342/3,365). There was no statistically significant difference in the increase of hemoglobin, hematocrit, and red blood cell between the period when erythrocyte autoantibodies were detected or not, (p = 0.27, 0.13, and 0.09, respectively).ConclusionErythrocyte autoantibodies positivity found on routine cross-match exmination, which must be considered together with parameters such as previous transfusion history, other pre-transfusion laboratory test results, and clinical presentation and management. Key Words: Transfusion, Erythrocye autoantibody, Alloantibody, Hemogram, Cross-matching.

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