• Marina Lampalo, Irena Jukić, Jasna Bingulac-Popović, Stanić Hana Safić HS 1Jordanovac University Department for Lung Diseases, Zagreb University Hospital Centre, Zagreb, Croatia; 2Croatian Institute of Transfusion Medicine,, Blaženka Barišić, and Sanja Popović-Grle.
• 1Jordanovac University Department for Lung Diseases, Zagreb University Hospital Centre, Zagreb, Croatia; 2Croatian Institute of Transfusion Medicine, Zagreb, Croatia; School of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia; 3Department of Molecular Diagnosis, Croatian Institute of Transfusion Medicine, Zagreb, Croatia.
• Acta Clin Croat. 2019 Dec 1; 58 (4): 590-594.

AbstractDuring a two-year period (2001-2003), 464 patients were treated for tuberculosis at Jordanovac Department for Lung Diseases in Croatia. Besides pulmonary tuberculosis in 97.7% of patients, patients were also treated for tuberculous pleurisy (0.9%), tuberculous laryngitis (0.6%), tuberculous meningitis (0.2%), tuberculous pericarditis (0.2%) and urogenital tuberculosis (0.4%). Out of the total number of patients, 57.3% declared themselves to be active smokers (men were predominant and made up to 80.8%) and 20.9% to be active alcohol consumers. Both risk factors, i.e. smoking and alcohol consumption, were present in 15.1% of all patients. The most common comorbidities were diabetes mellitus (30.4%), cardiac diseases (11.2%) and chronic obstructive pulmonary disease (8.0%). Lung carcinoma was the most common malignant disease (n=51), with Mycobacterium tuberculosis isolated in 33% of them. Seventy-two of 464 (15.5%) patients had recurrences of tuberculosis. Of these, 30.5% had one of the risk factors (20.8% were smokers and 9.7% consumed alcohol), while 32.5% of patients had both risk factors. In conclusion, cigarette smoking was proved to be the most significant risk factor for development of pulmonary tuberculosis and its recurrence.

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