• Patricia Reisz Majić, Branimir Cerovski, Petar Majić, Ivan Krković, Josip Barać, and Ivanka Bradvica Štenc.
• 1Department of Ophthalmology and Optometry, Faculty of Medicine, Osijek University Hospital Centre, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia; 2Department of Ophthalmology and Optometry, School of Medicine, Zagreb University Hospital Centre, Zagreb, Croatia; 3Department of Radiology, Vukovar General Hospital, Vukovar, Croatia; 4Department of Neurology, Faculty of Medicine, Osijek University Hospital Centre, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia.
• Acta Clin Croat. 2019 Dec 1; 58 (4): 639-646.

AbstractPterygium is a multifactorial proliferative pathologic change of bulbar conjunctiva. The purpose of this study was to determine the effect of the duration of exposure to solar radiation (expressed in years) on the incidence of positive cyclooxygenase-2 (COX-2) finding in conjunctival tissue in two groups of patients. Group 1 consisted of 68 patients with primary pterygium having undergone conjunctival autograft transplantation. Group 2 consisted of 43 patients with morphologically unchanged conjunctivae that were harvested during cataract surgery. All 111 specimens were submitted to immunohistochemical staining for monoclonal COX-2 antibody (1:100; M361701 MO A-HU, Dako, Santa Clara, California, USA). The immunostaining intensity in the surface epithelium was scored using the following grading system: 0 no immunostaining; + weak immunostaining (few cells being positive focally or scattered); ++ medium immunostaining; and +++ strong immunostaining (diffuse staining throughout the tissue). The analysis of COX-2 activity yielded 29 (42.6%) positive findings in group 1 and 27 (62.8%) positive findings in group 2. Group 2 consisted of statistically significantly older individuals with a history of considerably longer sun exposure. Statistical analysis proved the duration of exposure to solar radiation to be the most important factor in positive COX-2 findings.

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