• Am J Emerg Med · Jan 2021

    Case Reports

    Fluconazole-induced acute generalized exanthematous pustulosis.

    • Elie Saliba, Remie Chrabieh, and Zeina Tannous.
    • Department of Dermatology, Lebanese American University Medical Center - Rizk Hospital, Beirut, Lebanon. Electronic address: elie.saliba01@lau.edu.
    • Am J Emerg Med. 2021 Jan 1; 39: 254.e5-254.e7.

    AbstractAcute generalized exanthematous pustulosis (AGEP) is a rare severe cutaneous adverse reaction usually caused by drugs. The annual incidence is one to five cases per million. It is characterized by an acute febrile episode, accompanied by numerous small primarily non-follicular, sterile pustules arising within large areas of edematous erythema. There have been several case reports to date of AGEP following exposure to antifungals. Terbinafine is most commonly implicated in AGEP. We report a case of 7-year-old boy who developed AGEP shortly after commencing oral fluconazole for Tinea capitis. To our knowledge, this is the fourth reported case of AGEP due to fluconazole.Copyright © 2020 Elsevier Inc. All rights reserved.

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