• Cleve Clin J Med · Jul 2020

    Cytokine release syndrome and the prospects for immunotherapy with COVID-19. Part 2: The role of interleukin 1.

    • Leonard H Calabrese and Cassandra Calabrese.
    • Department of Rheumatic and Immunologic Diseases, Orthopedic & Rheumatologic Institute, Cleveland Clinic; Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH calabrl@ccf.org.
    • Cleve Clin J Med. 2020 Jul 9.

    AbstractInterleukin 1 (IL-1) is a potential target of therapy in COVID-19 during the severe respiratory-inflammatory phase ("cytokine release syndrome"), when pulmonary macrophages are hyperactivated, releasing IL-1 and other cytokines. Preliminary evidence indicates that anakinra and canakinumab, drugs that block the action of IL-1 and have a good safety profile, improve the outcomes of patients with COVID-19 cytokine release syndrome. Results from large, randomized clinical trials are pending.Copyright © 2020 The Cleveland Clinic Foundation. All Rights Reserved.

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