• Medicine · Feb 2019

    Meta Analysis

    Herbal medicine (Zhengan Xifeng Decoction) for essential hypertension protocol for a systematic review and meta-analysis.

    • Yonglian Huang, Yanhong Chen, Hairong Cai, Dongjie Chen, Xiaoming He, Zhixiong Li, Xiaojing Cai, Xiaohong Peng, Yaxiu Huang, Shaoping Li, Qifeng Cao, Ping Wang, and Bojun Chen.
    • Department of Critical Care Medicine, Beijing University of Chinese Medicine Shenzhen Hospital.
    • Medicine (Baltimore). 2019 Feb 1; 98 (6): e14292e14292.

    BackgroundEssential hypertension is one of the most common chronic diseases worldwide, as well as a leading risk factor for cardiocerebrovascular diseases. Zhengan Xifeng Decoction (ZGXFD) has been widely used to treat essential hypertension, but there is no systematic review by assessing efficacy and safety of ZGXFD on essential hypertension. Therefore, we aim to perform systematic review and meta-analysis to evaluate the efficacy and safety of ZGXFD in the treatment of essential hypertension.MethodsThis systematic review and meta-analysis will be performed by means of electronic databases, including EMBASE, Cochrane Center Registration Controlled trials (Cochrane Library), Web of Science (WOS), World Health Organization International Clinical Trials Registry Platform, PubMed, China Biomedical Literature Database (CBM), China National Knowledge Infrastructure (CNKI), Chinese Scientific Journal Database (VIP), and Wan-fang database. The electronic databases will be searched from their inception to October 2018. This systemic review will include only published English and Chinese articles randomized controlled trials (RTCs) of ZGXFD on essential hypertension. The primary outcome is Efficacy and blood pressure (BP), blood lipid and adverse reactions will be accepted as secondary outcomes. All statistical analyses will be conducted using RevMan V.5.3.5 software.ResultsThis systematic review and meta-analysis will provide high-quality evidence from several aspects, including for efficacy, blood pressure, blood lipid and adverse effects to evaluate the efficacy and safety of ZGXFD on EHTN.ConclusionThis systematic review will determine whether or not ZGXFD is an effective intervention for essential hypertension.

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