• A&A practice · Jun 2020

    Case Reports

    Substantial Elevation of Liver Enzymes During Ketamine Infusion: A Case Report.

    • Xiaoying Zhu, Lynn R Kohan, and Robert B Goldstein.
    • From the Department of Anesthesiology, Pain Management Center, University of Virginia Health System, Charlottesville, Virginia.
    • A A Pract. 2020 Jun 1; 14 (8): e01239.

    AbstractIntravenous infusion of a subanesthetic dose of ketamine has been shown to improve neuropathic pain. However, ketamine-induced liver injury can occur. Reported here are 2 cases with substantial liver enzyme elevations less than 2 days after initiation of repeat ketamine infusion at least 7 months after the last infusion. Although their liver enzymes normalized within a few weeks, it is unclear what the long-term consequences are. Furthermore, drug-induced liver injury can cause acute liver failure. Therefore, we recommend close monitoring of liver enzymes every 1 to 2 days during ketamine infusions.

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