• Int J Med Sci · Jan 2020

    Analyzing Functional Pathways and constructing gene-gene network for Narcolepsy based on candidate genes.

    • Hui Ouyang, Zechen Zhou, Qiwen Zheng, and Jun Zhang.
    • Department of Neuromedicine, Peking University People's Hospital, Beijing, China.
    • Int J Med Sci. 2020 Jan 1; 17 (11): 150815141508-1514.

    AbstractAims: To investigate the interactions among narcolepsy-associated genes and reveal the pathways these genes involved through bioinformatics analyses. Methods: The study was performed with the following steps: 1) Selected the previously discovered narcolepsy risk genes through literature review, 2) pathway enrichment analysis, and construction of gene-gene and protein-protein interaction (PPI) networks for narcolepsy. Results: 1) GO analysis revealed the positive regulation of interferon-gamma production as the most enriched terms in biological process, and C-C chemokine receptor activity as the most enriched term in molecular function, 2) KEGG pathway enrichment analysis revealed selective enrichment of genes in cytokine-cytokine receptor interaction signaling pathways, and 3) five hub genes were identified (IFNAR1, IL10RB, DNMT1, TNFSF4 and NFATC2). Conclusion: The bioinformatics results provide new insights into the molecular pathogenesis of narcolepsy and the identification of potential therapeutic targets for narcolepsy treatment.© The author(s).

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