• Sana Kaleem, Rabia Ghafoor, and Sidra Khan.
• Dr. Sana Kaleem, MBBS, FCPS II Trainee., Department of Dermatology, Jinnah Postgraduate Medical Centre, Karachi, Pakistan.
• Pak J Med Sci. 2020 Jul 1; 36 (5): 930-934.

ObjectivesTo compare the efficacy of tranexamic acid mesotherapy versus 0.9% normal saline for melasma by split-face study.MethodsIt was a non-randomized clinical trial performed at the Dermatology ward of JPMC from September 2018 to June 2019 after getting approval from the Ethical Committee. A total of sixty patients were recruited in the study, who had symmetrical melasma on their faces. Both halves of the face were treated by Injection Tranexamic Acid (TA) with a dose of 4mg/ml and Normal Saline (NS) two weekly for twelve weeks. Hemi Modified Melasma Area and Severity Scoring (H-mMASI) was calculated at the start and end of the study. Analyses were done by SPSS version 23. P < 0.05 was taken as significant.ResultsMean of H-mMASI score was compared on both sides at the end of study, which showed significant reduction in mean score from 3.19 ±2.57 to 1.52 ± 1.2 (P < 0.05) on A side as compared to decline in scores on NS side from 3.46 ± 2.7 to 3.45 ± 2.6 (P > 0.05). Erythema, swelling, and burning were documented as temporary side effects on both sides.ConclusionTranexamic Acid (TA) mesotherapy can be considered as the most cost-effective, safe and directly observed therapy for melasma which showed significant improvement when old prior therapies have failed.Copyright: © Pakistan Journal of Medical Sciences.

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