• Kadir Kaan Özsin, Abdullah Burak Balci, Umut Serhat Sanri, Orhan Guvenc, and Senol Yavuz.
• Department of Cardiovascular Surgery, University of Health Sciences, Bursa Yuksek Ihtisas Training & Research Hospital, Bursa, Turkey.
• J Coll Physicians Surg Pak. 2020 Jun 1; 30 (6): 561-567.

ObjectiveTo investigate the effect of ischemia-modified albumin (IMA) during cardiopulmonary bypass (CPB).Study DesignObservational study.Place And Duration Of StudyDepartment of Cardiovascular Surgery, Yuksek Ihtisas Training and Research Hospital, Bursa, Turkey, between January and April 2018.MethodologyPatients, who underwent on-pump coronary bypass surgery, were inducted. IMA levels were measured in the preoperative period (IMA-T1), 30 minutes after removal of aortic X-clamp (IMA-T2) (ischemic period) and 6th hours (IMA-T3) after surgery. The groups were formed according to the average value of IMA-T2 levels measured in the ischemic period. Those with a value above the mean (0.76 U/mL) were grouped as group 1 and those below the mean were grouped as group 2. Postoperative data of the patients were recorded.ResultsThere were significant differences between measured IMA levels in different periods of on-pump CABG (p <0.001). The development of postoperative atrial fibrillation (PoAF) was higher in Group 1 and this result was statistically significant (p=0.004). High IMA-T2 levels were detected as an independent parameter in predicting the PoAF development (p=0.04, logistic regression analysis). ROC curve analysis demonstrated  IMA-T2 values of 0.73 or above could predict development PoAF with 82.6% sensitivity and 66.7% specificity (AUC: 0.777, log rank p=0.001).ConclusionIncreased IMA levels during ischemic period may be predictive in PoAF development. Key Words: Cardiopulmonary bypass, Myocardial ischemia, İschemia-modified albumin.

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