• J Coll Physicians Surg Pak · Jun 2020

    Expression of p53 Protein in Prostate Carcinoma and its Correlation with Gleason Grade.

    • Zakia Wahid, Rozina Jaffer, Sobia Khalid, Haseeb Ahmed Khan, and Sabiha Riaz.
    • Department of Pathology, Fatima Memorial Hospital, Shadman, Lahore, Pakistan.
    • J Coll Physicians Surg Pak. 2020 Jun 1; 30 (6): 643-645.

    ObjectivesTo determine the correlation of p53 expression with Gleason score in prostate cancer.Study DesignDescriptive study.Place And Duration Of StudyDepartment of Pathology, Fatima Memorial Hospital, Lahore; from January 2014 to August 2016.MethodologyThirty-seven samples of prostate carcinoma were graded using Gleason grading system. p53 expression was detected through routine immunohistochemical staining protocols and assessed semi-quantitatively using four-point scale score. The collected data was analysed statistically using Pearson's correlation coefficient.   Results: Out of a sample of 37, high grade tumours were observed in 21 (57%) cases, making them the most prevalent type; while, p53 positive nuclear staining was observed in 26 (70%) cases. Within the high grade tumours, strong positive p53 expression was observed in 8 (38%) tumours; while, overexpression of p53 protein was seen in 7 (33%) cases. In contrast, overexpression of p53 was absent in low grade tumours.ConclusionA statistically significant correlation was observed between p53 positive expression and high Gleason grade. Key Words: Prostate cancer, Immunohistochemistry, p53 protein, Gleason score.

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