• Lidija Banjac, Jelena Kotur-Stevuljević, Tamara Gojković, Vesna Bokan-Mirković, Goran Banjac, and Gorica Banjac.
• 1Department of Neonatology, Clinical Center of Montenegro, Podgorica, Montenegro; 2Institute of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia; 3Center for Physical Medicine and Rehabilitation, Clinical Center of Montenegro, Podgorica, Montenegro; 4Institute of Children's Diseases, Clinical Center of Montenegro, Podgorica, Montenegro; 5The Obstetrics and Gynaecology Clinic Narodni Front, Belgrade, Serbia.
• Acta Clin Croat. 2020 Mar 1; 59 (1): 91-96.

AbstractInsulin-like growth factor 1 (IGF-1) is a regulator of intrauterine growth, and circulating concentrations are reduced in intrauterine growth-restricted fetuses. The aim of our study was to investigate the relationship between IGF-1 levels in newborns and intrauterine growth, expressed as birth weight (BW). The research was designed as a cross-sectional study. The study included 71 premature newborns, gestational age (GA) ≤33 weeks. Quantitative determination of IGF-1 was performed in the 33rd post-menstrual week (pmw) to make the measurements more comparable. We used an enzyme-bound immunosorbent test for quantitative determination of IGF-1. Our results showed the mean IGF-1 level in premature newborns in 33rd pmw to be 23.1±4.56 (range 15.44-39.75) µg/L. There was no difference in IGF-1 values between male (23.1±4.98 µg/L) and female (23.1±4.87 µg/L) newborns. There was no significant difference in the average IGF-1 levels between male and female newborns with BW <50th and BW >50th percentile for GA either (p>0.50). Only BW <33rd percentile newborns had a statistically significantly lower IGF-1 level compared to newborns with greater BW. Based on our results, it is concluded that serum IGF-1 level reflects intrauterine growth only in BW <33rd percentile newborns. This fact could be used for further therapeutic purposes.

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